This table summarizes the findings of the Page and Schroeder 1976 study. You can read more on the Page and Schroeder 1976 study in this post.
Stage |
Key Features |
| Initial Lesion 2-4 days |
After 2 to 4 days of plaque accumulation, inflammation develops. Neutrophils and macrophages develop. Although the cellular response develops in 2 to 4 days, the gingival looks healthy. |
| Early Lesion 1 week |
After 1 week of plaque accumulation, the lesion progress to a greater level of inflammation. The inflammatory infiltrate dominated by lymphocytes and neutrophils. Rete peg proliferation and some coronal epithelium is gone. There is vascular proliferation. |
| Established Lesion 14-21 days |
Occurs at 14 to 21 days. 10% to 30% plasma cells. Extravascular IgG is present. Rete pegs distribute to connective tissue. Pocket epithelium is leaky because of the junctional epithelium is now pocket epithelium. |
| Advanced Lesion |
Plaque further extends into the pocket. Plasma cells predominate. Loss of connective tissue and alveolar bone. True periodontal pocket develops. Irreversible clinical attachment loss. |
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