This table summarizes the findings of the Page and Schroeder 1976 study. You can read more on the Page and Schroeder 1976 study in this post.
|After 2 to 4 days of plaque accumulation, inflammation develops.
Neutrophils and macrophages develop.
Although the cellular response develops in 2 to 4 days, the gingival looks healthy.
|After 1 week of plaque accumulation, the lesion progress to a greater level of inflammation.
The inflammatory infiltrate dominated by lymphocytes and neutrophils.
Rete peg proliferation and some coronal epithelium is gone.
There is vascular proliferation.
|Occurs at 14 to 21 days.
10% to 30% plasma cells.
Extravascular IgG is present.
Rete pegs distribute to connective tissue.
Pocket epithelium is leaky because of the junctional epithelium is now pocket epithelium.
||Plaque further extends into the pocket.
Plasma cells predominate.
Loss of connective tissue and alveolar bone.
True periodontal pocket develops.
Irreversible clinical attachment loss.